منابع مشابه
Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the human body. Here we demonstrate that 13C-labelled zymonic acid (ZA) can be used as hyperpolarized magnetic resonance pH imaging sensor. ZA is synthesized from [1-13C]pyruvic acid and its 13C resonance frequencies shift up to 3.0 p.p.m. per p...
متن کاملImaging brain pH using hyperpolarized
F. A. Gallagher, M. I. Kettunen, D-E. Hu, L. B. Jarvis, R. L. McLaughlin, T. H. Witney, S. E. Day, J. H. Ardenkjaer-Larsen, K. G. Smith, and K. M. Brindle Radiology, University of Cambridge, Cambridge, United Kingdom, CRUK Cambridge Research Institute, Cambridge, United Kingdom, Biochemistry, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, Universit...
متن کاملMapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1‐13C]pyruvate
PURPOSE To demonstrate the feasibility of mapping intracellular pH within the in vivo rodent heart. Alterations in cardiac acid-base balance can lead to acute contractile depression and alterations in Ca2+ signaling. The transient reduction in adenosine triphosphate (ATP) consumption and cardiac contractility may be initially beneficial; however, sustained pH changes can be maladaptive, leading...
متن کاملDynamic 1H imaging of hyperpolarized [1‐13C]lactate in vivo using a reverse INEPT experiment
PURPOSE Dynamic magnetic resonance spectroscopic imaging of hyperpolarized 13 C-labeled cell substrates has enabled the investigation of tissue metabolism in vivo. Currently observation of these hyperpolarized substrates is limited mainly to 13 C detection. We describe here an imaging pulse sequence that enables proton observation by using polarization transfer from the hyperpolarized 13 C nucl...
متن کاملImaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 3Department of Clinical Medicine, MR Research Centre, Aarhus University Hospital, Aarhus, Denmark; 4Neurobiology Research Unit, Rig...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms15126